The Settle–Carlisle line (also known as the Settle and Carlisle (S&C)) is a 73-mile-long (117 km) main railway line in northern England. The route, which crosses the remote, scenic regions of the Yorkshire Dales and the North Pennines, runs between Settle Junction, on the Leeds–Morecambe line, and Carlisle, near the English-Scottish borders. The historic line was constructed in the 1870s and has several notable tunnels and viaducts such as the imposing Ribblehead.

The line is managed by Network Rail. All passenger services are operated by Northern apart from temporary diverted services (due to closures of the West Coast Main Line) and are part of the National Rail network. Stations serve towns such as Settle in North Yorkshire, Appleby-in-Westmorland in Cumbria and small rural communities along its route.

In the 1980s, British Rail planned to close the Settle–Carlisle line. This prompted a campaign to save the line by rail groups, enthusiasts, local authorities and residents along the route. In 1989, the UK government announced the line would be saved from closure. Since then, passenger numbers have grown steadily to 1.2 million in 2012. Eight formerly closed stations have been reopened and several quarries have been reconnected to the line. It remains one of the most popular railway routes in the UK for charter trains and specials. After damage by a landslip, part of the line was closed from February 2016 to March 2017. To celebrate the reopening, the first regular mainline scheduled service in England for nearly half a century ran with a steam engine.